![]() ![]() Here we describe unbiased fragment and DNA-encoded library (DEL) screening approaches for discovering LC3 small-molecule ligands. Modulation of interactions of mAtg8 with its target proteins via small-molecule ligands would enable further interrogation of their function. The mAtg8 proteins play essential roles in the formation and maturation of autophagosomes and the capture of specific cargo through binding to the conserved LC3-interacting region (LIR) sequence within target proteins. In humans, this process is driven by the mammalian Atg8 (mAtg8) family of proteins comprising the LC3 and GABARAP subfamilies. ![]() Weather isn’t your only problem though – be careful when dealing with terrorist attacks and gang wars.Autophagy-related proteins (Atgs) drive the lysosome-mediated degradation pathway, autophagy, to enable the clearance of dysfunctional cellular components and maintain homeostasis. Try to tame big wildfires spreading across the map. Watch out for extreme conditions that may lead to cataclysms and natural disasters. Watch the incidents change as day or night comes, traffic increases and seasons pass. Choose from over 100 000 areas, such as districts, municipalities, and tens of thousands of real cities from all over the world.įace the dynamic weather, based on authentic, historical data. Full 3D visualization will give you the inside view of your units’ actions. ![]() ![]() Lets you act on many, completely different levels – from taking care of a single neighborhood to coordinating several operators’ work in the world’s biggest metropolises. Help the city survive escalating events like riots, organized crime, terrorist attacks, cataclysms, natural disasters and many more! Genre: Simulation, Strategy, Management, Casualġ12 Operator allows you to manage emergency services in any city in the world! Dispatch units, take calls and face situations caused by weather, traffic or changing seasons. ![]()
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